endstream Må kun udleveres fra sygehus eller speciallæge. Store in a refrigerator (2°C - 8°C). Ovitrelle anvendes ved barnløshed, som skyldes manglende ægløsning. endstream when optimal stimulation of follicular growth is achieved. • Anovulatory or oligo-ovulatory adult women: Ovitrelle is administered to trigger ovulation and luteinisation in anovulatory or oligo-ovulatory women after stimulation of follicular growth. In women, chorionic gonadotropin acts as a surrogate luteinising hormone surge that triggers ovulation. -�"���-���6��62��.�'�x=�tvr=R��b��� �v�f@��=�2�H�B��`q��t��C�Ż��c�nVʚ��pp��u=8�����p� Ovitrelle 250 mikrogrammaa injektioneste, liuos, esitäytetyssä kynässä. x�S�*�2T0 B �ghnfn d'�r����f`Idvr��~D���K�B W � � 27 0 obj endstream Główna aktywność farmakodynamiczna u kobiet polega na wznowieniu mejozy w komórce jajowej, pęknięciu pęcherzyka (owulacja), utworzeniu ciałka żółtego i wytwarzaniu pr… maternal age, sperm characteristics) and the higher incidence of multiple pregnancies. The incidence of pregnancy loss by miscarriage or abortion is higher in patients undergoing stimulation of follicular growth for ovulation induction or ART than following natural conception. Léčivý přípravek Ovitrelle je buď prášková forma léku k přípravě injekčního roztoku s rozpouštědlem a nebo již hotová naplněná injekční stříkačka roztokem, či předplněné pero, které se používá ke spuštění ovulace. Generally… �2P�01RI�r � - Ponechte si příbalovou informaci pro případ, že si ji budete potřebovat přečíst znovu. Treatment with Ovitrelle should be performed under the supervision of a physician experienced in the treatment of fertility problems. In distinction to uncomplicated ovarian enlargement, OHSS is a condition that can manifest itself with increasing degrees of severity. Before starting treatment, the couple's infertility should be assessed as appropriate and putative contraindications for pregnancy evaluated. Ovitrelle was as effective as urinary hCG in triggering ovulation, and the 250-microgram dose of Ovitrelle was as effective as the 500-microgram dose. A comparative study between the freeze-dried and the liquid formulation showed bioequivalence between the two formulations. In the absence of compatibility studies, this medicinal product must not be mixed with other medicinal products. This is thought to be due to differences in parental characteristics (e.g. endobj <>stream Mielőtt megkezdené az Ovitrelle előretöltött injekciós toll használatát 3. Caso não seja utilizado durante esses 30 dias, deverá ser rejeitado. (Orifarm) Kr. Da hatte ich Angst, dass ich doch noch Spritzenreste „teste“ aber ich bin tatsächlich schwanger. The following definitions apply to the frequency terminology used hereafter: very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000), not known (cannot be estimated from the available data). There is evidence to suggest that hCG plays a key role in triggering OHSS and that the syndrome may be more severe and more protracted if pregnancy occurs. <>stream Ovitrelle is not indicated during breastfeeding. Nonclinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity and genotoxicity. x�S�*�2T0 B �ghnfn d'�r����f`Idvr��~D���K�B W �' � Within its shelf-life, the solution may be stored at or below 25°C for up to 30 days without being refrigerated again during this period. wenn bei Ihnen eine Vergrößerung der Eierstöcke oder mit dick- oder dünnflüssigem Inhalt gefüllte Blasen in den Eierstöcken (Eierstockzysten) unbekannter Herkunft vorliegen. To email a medicine you must sign up and log in. How has Ovitrelle been studied? Kvinner som gjennomgår superovulasjon før assistert befruktning som f.eks. Přečtěte si pozorně celou příbalovou informaci dříve, než začnete tento přípravek používat, protože obsahuje pro Vás důležité údaje. Ved ovariel stimulation som led i intaruterin insemination eller in vitro-fertilisering gives 250 mikrogram hCG, når ledende follikel er 18-20 mm. The steady-state volume of distribution and the total clearance are 6 L and 0.2 L/h, respectively. In particular, patients should be evaluated for hypothyroidism, adrenocortical deficiency, hyperprolactinemia and pituitary or hypothalamic tumours, and appropriate specific treatment given. (Paranova) Kr. It is more commonly seen in women with polycystic ovarian syndrome and usually regresses without treatment. Severe OHSS further includes symptoms such as severe ovarian enlargement, weight gain, dyspnoea or oliguria. Hey man sagt, dass es nach 10 Tagen raus ist. For subcutaneous use. 16 0 obj There have been reports of ovarian and other reproductive system neoplasms, both benign and malignant, in women who have undergone multiple treatment regimens for infertility. - Uputstvo sačuvajte. gespritzt. Studies on reproduction were not performed in animals. 30 0 obj Ovitrelle has mainly been studied in women undergoing fertility treatment (1,140 patients). https://www.institutobernabeu.com/de/Sein Wirkstoff ist das rekombinante Hormon hCG (Humanes Choriongonadotropin). Mild manifestations of OHSS may include abdominal pain, abdominal discomfort and distension, and enlarged ovaries. Merck Serono Ltd, 5 New Square, Bedfont Lakes Business Park, Feltham, Middlesex, TW14 8HA, UK. Following subcutaneous administration, choriogonadotropin alfa is eliminated from the body with a terminal half-life of about 30 hours, and the absolute bioavailability is about 40%. Renal or hepatic impairment. Multiple pregnancies, especially high order, carry an increased risk of adverse maternal and perinatal outcomes. Doseringsforslag. x�]��n� ���w�;T4iw�*M�*��mZ6�L�I�@���%e����o^���� ��[�`�N�q���-�ڰ��e�D��c7�p�Mga�TjrYɿ���a�l�/��c��+��������k&��8� �#�n��p�b@��c[�(�a���?����ĿW�0�)�Sd�NH���Ȏ��Np��uZJ��MQm'o¯j2D��O�'*3��Jη�[Ʒv&'�cS4=�ŧk��78�h q�e�p Pharmacotherapeutic group: Sex hormones and modulators of the genital system, gonadotropins, ATC code: G03GA08. Ovitrelle is indicated for use in infertility (see section 4.1). <>stream endobj 8 0 obj <>stream endobj 17 0 obj Mild to severe hypersensitivity reactions including rash, anaphylactic reactions and shock, Thromboembolism (both in association with and separate from OHSS), Abdominal pain, abdominal distension, nausea, vomiting, General disorders and administration site conditions. <>stream Ich löse mit Ovitrelle aus und spritze eine Woche später nochmal nach. x� One pre-filled syringe of Ovitrelle (250 micrograms) is administered 24 to 48 hours after optimal stimulation of follicular growth is achieved. Detailed information on this medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu. endobj To minimise the risk of higher order multiple pregnancy, careful monitoring of ovarian response is recommended. The maximum dose is 250 micrograms. endobj !n�h{�7�C����0�Z��6T.�Dڲ�Hv{�,�w���t-8}�s-ݔ��F��G�d�c�zz��Ɋ'M�f���z{���x�{ �1'ú"Y�,��"��ȇ\ 6�Y4ZC��G�j�8�[(Rr��Om " ��iL�sX3�Y����=��.���*�����޵�6]rK��*�~�5�6��`�Q/��s(�N��U�@�"�nT��h*xf��*�C[�� �^5~��W�� Din läkare har förklarat exakt när injektion en ska tas. There are no indications that choriogonadotropin alfa is metabolised and excreted differently than endogenous hCG. Gonadotropina kosmówkowa wiąże się z przezbłonowym receptorem LH/CG, komórek otoczki (i warstwy ziarnistej) jajnika, do którego przyłącza się także hormon luteinizujący. Ovitrelle 250mcg/0.5ml injekcinis tirpalas užpildytame švirkšte 0.5ml N1 + 1 adata. Az adag beállítása - "Az adag beállítása 250-re" 5. 24730.01.05 ovitrelle ps.inj.sol 250mcg/1ml vial btx2vials+2vialsx1ml 57,26 € 65,82 € 92,81 € Each pre-filled syringe contains 250 micrograms choriogonadotropin alfa* (equivalent to approximately 6,500 IU) in 0.5 mL solution. If severe OHSS occurs, it is recommended that gonadotropin treatment be stopped and that the patient be hospitalised and appropriate therapy be started. Mild or moderate OHSS usually resolves spontaneously. <>>>/Subtype/Form/BBox[0 0 595 842]>>stream n�Dk6!��T[�����!�)��I�56)i6��Sb_���8��w�|k�{~v��G��F���ť>�/�q4:A�i�T�D���ۗ@�KO�ʰ1Ef%��6���}�o�ȋv6���k'yч��^ Q����s@NO߯����������y ���,�iǹgU�dԇ���H[yGz���sjz��;��}�6���ؗ��j���ta�r�K g�jiIc�! �2P�01RI�r � dose er 250 μg. Ovitrelle 250 mikrogramů, injekční roztok v předplněném peru. Ovitrelle (250 of 500 microgram) werd vergeleken met het natuurlijke hCG- hormoon, verkregen uit urine. Qualitative and quantitative composition, 4.2 Posology and method of administration, 4.4 Special warnings and precautions for use, 4.5 Interaction with other medicinal products and other forms of interaction, 4.7 Effects on ability to drive and use machines, 6.6 Special precautions for disposal and other handling, 9. ����s��w'�-B�UZ�QN�F���N��9oN�#��ͦ�:��}���{�{ߟ�}�v7@ `�% �3�ArEѐQ�قMCY� Y��Ў��w!����v��#��u; �������yUȶG7������Yc�7kz endstream 18 0 obj Severe OHSS was reported in less than 0.5% of patients (see section 4.4). <>/Subtype/Form/BBox[0 0 1 1]>>stream In women with recent thromboembolic disease or women with generally recognised risk factors for thromboembolic events, such as personal or family history, treatment with gonadotropins may further increase the risk for aggravation or occurrence of such events. • Hypersensitivity to the active substance or to any of the excipients listed in section 6.1, • Tumours of the hypothalamus or pituitary gland, • Ovarian enlargement or cyst unrelated to polycystic ovarian syndrome, • Gynaecological haemorrhages of unknown aetiology, Ovitrelle must not be used in conditions when an effective response cannot be obtained, such as, • malformations of sexual organs incompatible with pregnancy, • fibroid tumours of the uterus incompatible with pregnancy. 330,55 / Ovitrelle 250 mikrogram / 1 stk. Kr. Inainte de inceperea tratamentului cu Ovitrelle, spuneti medicului dumneavoastra sau farmacistului daca luati sau ati luat recent orice alte medicamente, inclusiv dintre cele eliberate fara prescriptie medicala. endobj Ovitrelle is hoofdzakelijk onderzocht bij vrouwen die een vruchtbaarheidsbehandeling ondergingen (1 140 patiënten). The patient is recommended to have coitus on the day of, and the day after, Ovitrelle injection. Om du ger dig själv Ovitrelle, ska du noga läsa och följa den separata ”Bruksanvisningen” som finns i kartongen. endobj <>stream OHSS was observed in approximately 4% of patients treated with Ovitrelle. Reporting suspected adverse reactions after authorisation of the medicinal product is important. Stosowanie leku. 24730.01.02 ovitrelle 2vials 250mcg+2amp solv 57,26 € 65,82 € 92,81 € serono hellas a.e. endstream <> <>stream Hatte eine Ovitrelle 250 mkrg. endobj Hur du använder detta läkemedel. 3 0 obj When suggestions are available use up and down arrows to review and ENTER to select. endobj Women with a history of tubal disease are at increased risk for ectopic pregnancy, whether the pregnancy is obtained by spontaneous conception or with fertility treatments. <>stream <>stream The prevalence of congenital malformations after ART may be slightly higher than after spontaneous conceptions. Ovitrelle is indicated in the treatment of. x�+� � | Independent risk factors for developing OHSS include young age, lean body mass, polycystic ovarian syndrome, higher doses of exogenous gonadotropins, high absolute or rapidly rising serum estradiol levels and previous episodes of OHSS, large number of developing ovarian follicles and large number of oocytes retrieved in ART cycles. endobj 11 0 obj The name recombinant means that it has not been purified using human substances. Continue typing to refine. There is no indication for the use of Ovitrelle during pregnancy. endstream <>stream x�+� � | <>stream <>/XObject<>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]/Font<>>>/Rotate 0/MediaBox[0 0 595.273 841.886]>> This is justified, given the proteinous nature of the active substance and the negative outcome of the genotoxicity testing. endstream endobj It is not yet established whether or not treatment with gonadotropins increases the risk of these tumours in infertile women. 15 0 obj Clear, colourless to slightly yellow solution. Može biti potrebno da ga ponovo pročitate. Ovitrelle 250 microgramas solução injectável pode ser conservado à temperatura ambiente (a ou abaixo de 25ºC) durante 30 dias sem voltar a ser colocado no frigorífico durante este período. This medicinal product contains less than 1 mmol sodium (23 mg) per dose, i.e. Moderate OHSS may additionally present with nausea, vomiting, ultrasound evidence of ascites and marked ovarian enlargement. The effectiveness of Ovitrelle was measured by looking at how many eggs were released. The potential risk for humans is unknown. 4 0 obj endobj %PDF-1.4 For the full list of excipients, see section 6.1. Lek Ovitrelle jest przeznaczony do podania podskórnego, to znaczy podaje się … Contraindicatii la administrarea Ovitrelle 250 … Az Ovitrelle 250 mikrogramm oldatos injekció a lejárati időn belül hűtés nélkül, szobahőmérsékleten (legfeljebb 25 °C-on) 30 napig tárolható újrahűtés nélkül, a 30 napon belül fel nem használt injekciót ki … Lekarz prowadzący dokładnie wyjaśni, kiedy należy podawać lek. One pre-filled syringe of Ovitrelle (250 micrograms) is administered 24 to 48 hours after optimal stimulation of follicular growth is achieved. Oplysningerne og priserne er altid opdaterede. Choriogonadotropin alfa. x�S�*�2T0 B �ghnfn d'�r����f`Idvr��~D���K�B W �� � There are no data on the excretion of choriogonadotropin alfa in milk. 29 0 obj In comparative trials with different doses of Ovitrelle, OHSS was found to be associated with Ovitrelle in a dose-related fashion. endstream Safety, efficacy and pharmacokinetics of Ovitrelle in patients with renal or hepatic impairment have not been established. endstream Ovitrelle 250 Mikrogramm Inj.-Lsg.i.e.Fe, 1 St., Merck Serono GmbH, jetzt günstig bei der Versandapotheke DocMorris bestellen x�+� � | *Rekombinantti ihmisen koriongonadotropiini, r‑hCG, on tuotettu kiinanhamsterin munasarjasoluissa yhdistelmä‑DNA‑tekniikalla. x�+�r However, the in-use stability has been demonstrated for 24 hours at + 2°C to 8°C. 5 0 obj �*T0T0 B�����f����� �6 � Healthcare professionals are asked to report any suspected adverse reactions via: Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store, Website: www.medicinesauthority.gov.mt/adrportal. <>/Subtype/Form/BBox[0 0 1 1]>>stream Az adag beadása 6. när optimal stimulering av follikeltillväxt har uppnåtts. Az Ovitrelle előretöltött injekciós toll előkészítése az injekció beadására 4. endstream Following administration, Ovitrelle may interfere for up to ten days with the immunological determination of serum or urinary hCG, potentially leading to a false positive pregnancy test. x�+� � | Chorionic gonadotropin binds on the ovarian theca (and granulosa) cells to a transmembrane receptor shared with the luteinising hormone, the LH/CG receptor. - A készítmény ajánlott adagja 1 db előretöltött fecskendőben lévő mennyiség (250 mikrogramm/0,5 ml), egyszeri injekcióban beadva. %���� koriongonadotropiini alfa. �*T0T0 B�����f����� �6 � Continue, 2. Clinical investigation in women for the indication of ART and anovulation was limited to one treatment cycle. ��������wNT�35�F�����yL����{.� x�+�r Ovitrelle destina-se apenas a administração única. x�� This site uses cookies. �V 24 0 obj it is essentially “sodium-free”. Lue tämä pakkausseloste huolellisesti ennen kuin aloitat tämän lääkkeen käyttämisen, sillä se sisältää sinulle tärkeitä tietoja. �zQ!�v;:�z��Dp��8�ƀN�*6��Q!��ga%�EΌ�l����3@�δ'���gv�y(X{�׺ �0P:pf�J��@�H��}⑸��KK\"Α�t�ùS��p�SoB~�م��U&�L�Sn���]�: �⻻�� �Ɠ�(*73q7�{�������-��u}��ã����AO^0Δlܙ2S)��r�vn��� �#8vgѡS�#k80`�ّ2y葑��J=��5ӈ]��\���� ��Ηe6�y����ë�!s�s KI���h���1��9��+�ҁV-��6X�﹒�����4��U���R�p9�� Maks. endstream Apart from its active substance, alfa choriogonadotropin 250 mg per 0.5 ml, as excipients, manitol 27,3 mg , L-methionine 0.1 mg and 0.5 mg of poloxamer 188 can be found. <>/CIDToGIDMap/Identity/BaseFont/BBXBIR+Tahoma/Subtype/CIDFontType2/W[0[1000 0 313 313 363]]>> ���Z�Z��jNS�J�>���k�ۆ��AIL��LO^��]v% Ovitrelle has no or negligible influence on the ability to drive and use machines. Zalecana dawka to zawartość jednej ampułko-strzykawki (250 mikrogramów/0,5 ml) podana w jednym wstrzyknięciu. x��Xpe߷I����mZJBٍK����oh��m�D�*-ma��G�&%0@�-zzDo.� <>stream 6 0 obj On the contrary, it is synthesized in the laboratory using genetic engineering techniques and its origin is artificial. Re: Testreihe nach Ovitrelle und Nebenwirkungen Post by Die2Engel » Sun Feb 05, 2017 10:49 am Ich hab den HCG Rechner im Internet bemüht, der sagt nach ca. 26 0 obj endobj endstream After opening, the medicinal product should be used immediately. Date of first authorisation/renewal of the authorisation. Rekommenderad dos är 1 förfylld injektionspenna (250 mikrogram/0,5 ml) som tas som en injektion. So far, there are no signs of antibody development in humans to Ovitrelle. De werkzaamheid van Ovitrelle werd gemeten aan de hand van het aantal vrijgekomen eicellen. There is no clinical experience with Ovitrelle in the treatment of other conditions (such as corpus luteum insufficiency or male conditions); therefore, Ovitrelle is not indicated in these conditions. Monitoring of stimulation cycles by ultrasound scans as well as estradiol measurements are recommended to early identify risk factors. endobj ��P��o�͘����&ԡ�/C`����TP(8���q��-�J�h� I��gru�����u���Py��i��V��,�K����-�Fg"_�$[;Ց�� wY���u��Ο�@���e:�-rU�n�ׅ�n�;ov����w6�$7N�����RG��ջ������0/uST�f�ڔ�҇[��#��TBd���;�ڞ $����4�㱅L潠�L�;�g4�O��l)�7;̷�\���D���W��v�BS�mHVg��ygS�*?[�W���\o����i�4��;.=�ti�mz/V,�B�;������b��VL7����p��J�}Ȋ�;�U�c5B�����B���\���W�ʦk$�}�A��B��K6U�۟��b:q�F~���}�������B����@�p��L�`�$�Q���tԓ2�����$fE�? endstream Bei mir war ein Test schon nach 7 Tagen negativ gewesen. 19 0 obj Start typing to retrieve search suggestions. endobj endobj It comprises marked ovarian enlargement, high serum sex steroids, and an increase in vascular permeability which can result in an accumulation of fluid in the peritoneal, pleural and, rarely, in the pericardial cavities. (2care4) Kr. Bemærk: Film om brug af Ovitrelle pen kan ses under "Instruktioner". Ovitrelle 250 Mikrogramm/0,5 ml Injektionslösung in einer Fertigspritze 2 008198-E679 – Ovitrelle 250 Mikrogramm/0,5 ml – n. anders metabolisiert oder ausgeschieden wird als endogenes hCG. endobj It should be noted, however, that pregnancy itself as well as OHSS also carry an increased risk of thromboembolic events. This information is intended for use by health professionals, Ovitrelle 250 micrograms/0.5 mL solution for injection in pre-filled syringe. ��\�j0n$� ����@��_�&�_E�3}¯���-�A�՘�}�کa�����Cw��v�z!�Q��K;.�/�'�z�~����m������4�����3�� �gl��S��=��2H��i�5�pN�w�?�r ����?���A��������e�!n��G!i��k�}�5�:Dg��.��4w�{n�kނ����|I���;��$�)}~���8�}8�_�6��!x\jH�u�_aJ���� ���~ #�`�܇��+���V� ������Qt?��c���smt�ʜ��I���W��xp��`�����I��2�;K�1xZն���~Lb�m���9W��IX��Ĉ�n8B�������� �>F�&!��mR�vNY�'�V!$GuG�o`3�K�9��E�����KH{�8h!�`�J�Q���xe�KJ�!e�͕"[ǹ%���V�#k�w!Ő�#M!��d ��uH;�t�iң�+wM P��U�R�o���������R��Y�(��7>��z�/)Q�b6����. A gyógyszer használata - Az Ovitrelle injekció szubkután alkalmazásra való, vagyis a … Any unused medicinal product or waste material should be disposed of in accordance with local requirements. - Kezelőorvosa el fogja Önnek pontosan magyarázni, mikor kell beadni az injekciót. Ovitrelle 250 Mikrogramm/0,5 ml enthält den Wirkstoff Choriongonadotropin. The principal pharmacodynamic activity in women is oocyte meiosis resumption, follicular rupture (ovulation), corpus luteum formation and production of progesterone and estradiol by the corpus luteum. endobj x� Ved in vitro-fertilisering bør hCG undlades, hvis der er stor risiko for ovarielt overstimulationssyndrom. Very rarely, severe OHSS may be complicated by ovarian torsion or thromboembolic events, such as pulmonary embolism, ischaemic stroke or myocardial infarction. Studies on carcinogenic potential were not performed. endobj endstream Interference with serum or urinary testing. Solution for injection in pre-filled syringe. Wenn Sie OVITRELLE 250 Mikrogramm Inj.-Lsg.i.e.Fertigpen kaufen möchten, wählen Sie bitte die gewünschte Menge aus und klicken Sie dann auf "in den Warenkorb". Ma analogiczną sekwencję aminokwasów jak hCG izolowana z moczu. endobj <> endstream Yksi esitäytetty kynä sisältää 250 mikrogrammaa koriongonadotropiini alfaa* (vastaten noin 6 500 IU). endstream It must be discarded if not used after these 30 days. x��X_��6?���¥��81����L���B?��W(ܕ���-K��?��pǒM&��_?��v�+���/�o��r�_y�e�Ҙ�0C����Ͽ����ϧ��ia���2ĥ|t���>�Կ�1�w�,������݇!������d.S]����s.�:��# A��RX|*�T�T����{)W����]��D4�r��������q,�n��W��w��� endstream 14 0 obj 28 0 obj One study was also carried out in women who could not ovulate. There is no relevant use of Ovitrelle in the paediatric population. Choriongonadotropin kann einen Mangel an bestimmten Geschlechtshormonen ausgleichen und dient zur Behandlung von Störungen der Fruchtbarkeit bei Frauen und Männern. * recombinant human chorionic gonadotropin, r-hCG produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology. Ovitrelle 250 mikrogram / 1 stk. Ovitrelle a été étudiée principalement chez des femmes suivant un traitement favorisant la fertilité (chez 1 140 patientes). Adherence to recommended Ovitrelle dosage and regimen of administration can minimise the risk of ovarian hyperstimulation. Ovitrelle is a medicinal product of choriogonadotropin alfa produced by recombinant DNA techniques. ovitrelle 1vial 250mcg+1vial solv 32,29 € 37,11 € 52,32 € serono hellas a.e. endobj No specific interaction studies with Ovitrelle and other medicinal products have been performed; however, no clinically significant medicinal product interactions have been reported during hCG therapy. Date of first authorisation: 02 February 2001. Nevertheless, there is a possibility that OHSS may result from an overdose of Ovitrelle (see section 4.4). By continuing to browse the site you are agreeing to our policy on the use of cookies. Wenn Sie ein Rezept haben, wählen Sie bitte zusätzlich aus, um welche Art von Rezept es sich handelt. x�+� � | Ob er schon eher negativ gewesen wäre weiß ich nicht, weil ich nie früher getestet habe. Ovitrelle syr 250mcg PIL (EMA 100122) ΦΥΛΛΟ ΟΔΗΓΙΩΝ ΧΡΗΣΗΣ : ΠΛΗΡΟΦΟΡΙΕΣ ΓΙΑ ΤΟΝ ΧΡΗΣΤΗ Ovitrelle 250 μικρογραμμάρια/0,5 ml, ενέσιμο διάλυμα σε προγεμισμένη σύριγγα Xοριακή γοναδοτροπίνη άλφα. 2 0 obj In these women, the benefits of gonadotropin administration need to be weighed against the risks. 328,85 / Ovitrelle 250 mikrogram / 1 stk. Repeated exposure to Ovitrelle was investigated in male patients only. To bookmark a medicine you must sign up and log in. <>>>/Subtype/Form/BBox[0 0 595 842]>>stream 2. Ovitrelle 250 mcg/0,5 ml, interactiuni medicamentoase. Nach subkutaner Anwendung wird Chorio-gonadotropin alfa mit einer terminalen Halb- 12 0 obj endstream Hogyan kell használni az Ovitrelle előretöltött injekciós tollat? 10 0 obj endobj endstream 6500 ie waren es und das bei 65 kg. Choriogonadotropin Alfa is used in the treatment of female infertility.It may be used in women as part of an assisted reproductive technique such as IVF (in vitro fertilisation). OVITRELLE injektioneste, liuos, esitäytetty kynä 250 mikrog Vaikuttavat aineet ja niiden määrät. <>stream Ovitrelle is used to trigger final follicular maturation and early luteinisation after use of medicinal products for stimulation of follicular growth. 0.5 mL of solution in a pre-filled syringe (type I glass) with a plunger stopper (halobutyl rubber) and plunger (plastic), and with a needle for injection (stainless) – pack of 1. • Adult women undergoing superovulation prior to assisted reproductive technologies (ART) such as in vitro fertilisation (IVF): Ovitrelle is administered to trigger final follicular maturation and luteinisation after stimulation of follicular growth. 7 0 obj Yleisiä ohjeita. endstream OVITRELLE 250 mcg/0.5 ml 1 kullanıma hazır şırınga Aktif 2021 Yılı yılı ilaç fiyatları listesi ve diğer yıllara ait satış fiyat grafikleri, eşdeğer ilaçlarının fiyatları, Türk İlaç Rehberi İlaç Fiyatları Sayfasında. As OHSS may progress rapidly (within 24 hours) or over several days to become a serious medical event, patients should be followed for at least two weeks after hCG administration. Store in the original package. A certain degree of ovarian enlargement is an expected effect of controlled ovarian stimulation. The following dose regimen should be used: • Women undergoing superovulation prior to assisted reproductive technologies (ART) such as in vitro fertilisation (IVF): One pre-filled syringe of Ovitrelle (250 micrograms) is administered 24 to 48 hours after the last administration of a follicle stimulating hormone (FSH) or human menopausal gonadotropin (hMG) preparation, i.e. endobj It may also be used in women who produce no eggs at all or too few eggs. To view the changes to a medicine you must sign up and log in. It shares the amino acid sequence with urinary hCG. x�+� � | ... Meine Tests waren in der Testreihe sehr schnell negativ und fix wieder positiv. The prevalence of ectopic pregnancy after ART in this population was reported to be higher than in the general population. Therefore, if signs of ovarian hyperstimulation occur, it is recommended that hCG be withheld and the patient be advised to refrain from coitus or use barrier contraceptive methods for at least 4 days. <>stream L’efficacité d’Ovitrelle a été évaluée à partir du nombre d’ovules libérés. x�S�*�2T0 B �ghnfn d'�r����f`Idvr��~D���K�B W � � Zu beachten ist außerdem die besondere Wirkung von Ovitrelle 250 Mikrogramm/0,5 ml. In patients undergoing ART procedures the risk of multiple pregnancy is related mainly to the number of embryos replaced, their quality and the patient age. endobj x�S�*�2T0 B �ghnfn d'�r����f`Idvr��~D���K�B W �� � Self-administration of Ovitrelle should only be performed by patients who are adequately trained and have access to expert advice. The pH of the solution is 7.0 ± 0.3, its osmolality 250-400 mOsm/kg. <>stream 13 0 obj 10 Tagen soll das künstliche HCG abgebaut sein. Anvendes ofte sammen med follikelstimulerende hormon (FSH). 20 0 obj <>stream Preparat jest choriogonadotropiną alfa otrzymywaną metodą rekombinacji DNA. No reproduction studies with choriogonadotropin alfa in animals were performed (see section 5.3). x�S�*�2T0 B �ghnfn d'�r����f`Idvr��~D���K�B W � � In order to improve the traceability of biological medicinal products, the name and the batch number of the administered product should be clearly recorded. Ovitrelle (250 micrograms or 500 micrograms) was compared with the natural hCG hormone that had been extracted from urine. Ovitrelle®, 250 mikrograma/0.5ml, rastvor za injekciju u napunjenom injekcionom špricu horiogonadotropin alfa Pažljivo pročitajte ovo uputstvo, pre nego što počnete da koristite ovaj lek. x�+� � | Findes som injektionsvæske, der indgives under huden. 9 0 obj endobj Following intravenous administration, choriogonadotropin alfa is distributed to the extracellular fluid space with a distribution half-life of around 4.5 hours. endstream Clinical evaluation may reveal signs such as hypovolaemia, haemoconcentration, electrolyte imbalances, ascites, pleural effusions, or acute pulmonary distress. It allows continued monitoring of the benefit/risk balance of the medicinal product. Only clear solution without particles should be used. x�S�*�2T0 B �ghnfn d'�r����f`Idvr��~D���K�B W � � The majority of multiple conceptions are twins. Its active substance is choriogonadotropin alfa, also named recombinant hCG, human choriogonadotropin. The patient is recommended to have coitus on the day of, and the day after, Ovitrelle injection. 331,10 / Ovitrelle 250 mikrogram / 1 stk. In comparative clinical trials, administration of a dose of 250 micrograms of Ovitrelle was as effective as 5,000 IU and 10,000 IU of urinary hCG in inducing final follicular maturation and early luteinisation in assisted reproductive technologies, and as effective as 5,000 IU of urinary hCG in ovulation induction. Self-administration of Ovitrelle should only be performed by patients who are adequately trained and have access to expert advice.
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